The Determinant Factor Of Intrinsic And Extrinsic Aging Essay

Is Aquaporin-3 a Determinant Factor of Intrinsic and Extrinsic Aging? An Immunohistochemical and Morphometric Study Iman Seleit, MD,* Ola A. Bakry, MD,* Hala S. El Rebey, MD,w Gehan El-Akabawy, MD,z and Gehan Hamza, MSc* Abstract: Aquaporin-3 (AQP3) is an aquaglyceroporin that plays a role in skin hydration, cell proliferation, and migration. The aim of this work was to investigate the expression of AQP3 in sun-exposed and sun-protected human skin from different age groups to understand the relationship between AQP3 and skin aging. Using standard immunohistochemical techniques, sunexposed and sun-protected skin biopsies were taken from 60 normal individuals. AQP3 was expressed in the basal and the suprabasal layers, sparing the stratum corneum, in all specimens. Dermal expression was detected in fibroblasts, endothelial cells, and adnexa. Sun-protected skin showed a significantly higher epidermal H-score and percentage of expression (P=0.002 and 0.001) were significantly associated with the age group (20 to 35 y) in sun-exposed skin. C, A higher H-score was significantly associated with the age group (20 to 35 y) in sun-protected skin (P 0.001). D, Comparison between the immunohistochemical expression of AQP3 in sun-exposed and sunprotected skin in different age groups. A higher percentage of expression was significantly associated with sun-protected skin in the age group of 20 to 35 years (P = 0.03), in the age group of 35 to 50 years (P = 0.007), and in the age groupShow MoreRelatedDefining Motivation : Well Known And Unsolved3147 Words   |  13 Pages2008). The nature of motivation has traditionally been separated into two qualitatively distinct forms: a) intrinsic interest and; b) extrinsic motivation (Deci Ryan, 1985). This assumption has served as the foundation of many psychological theories and experiments. 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